Antibacterial Inhibitor as an Expired Metoclopramide in 0.5M Phosphoric Acid

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Rana Afif Anaee Majed Hameed Abd Al-Majeed Shaimaa Alaa Naser Mustafa M. Kathem Omer Akram Ahmed


Expired drug Metoclopramide was investigated as an antibacterial corrosion inhibitor for carbon steel in 0.5M H3PO4 solution using the electrochemical method at 30oC and 60oC. The results showed that this drug is an efficient inhibitor for carbon steel and the efficiency reached to 82.244 % for 175 ppm at 30oC and 76.146% for 225 ppm at 60oC. The adsorption of drug on carbon steel surface follows Langmuir adsorption isotherm with small values of adsorption-desorption constant. The polarization plots revealed that Metoclopramide acts as mixed-type inhibitor. Some parameters of inhibition process were calculated and discussed. The surface morphology of the carbon steel specimens was analyzed using scanning electron microscope and energy dispersive X-ray analysis. Antibacterial activity of inhibitor was also tested. Fourier-transform infrared (FTIR) spectroscopy confirmed the inhibitive role of Metoclopramide drug.


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ANAEE, Rana Afif et al. Antibacterial Inhibitor as an Expired Metoclopramide in 0.5M Phosphoric Acid. Al-Khwarizmi Engineering Journal, [S.l.], v. 15, n. 1, p. 71- 81, mar. 2019. ISSN 2312-0789. Available at: <>. Date accessed: 23 mar. 2019. doi:


[1] A.S. Ekop and N.O. Eddy, “Inhibitive and adsorptive properties of Orphenadrine for the corrosion of mild steel in H2SO4ˮ, Australian Journal of Basic and Applied Sciences, Vol.2, No.4, , 1258–1263, 2008.
[2] N.O. Eddy, S. A. Odoemelam and A. J. Mbaba, “Inhibition of the corrosion of mild steel in HCl by Sparfloxacinˮ, African Journal of Pure and Applied Chemistry, Vol.2, No.12, 132–138, 2008.
[3] E.E. Ebenso, N.O. Eddy and A.O. Odiongenyi, “Corrosion inhibition and adsorption properties of Methocarbamol on mild steel in acidic mediumˮ, Portugaliae Electrochimica Acta, Vol.27, No.1, 13–22, 2009.
[4] N.O. Eddy, S.R. Stoyanov and E.E. Ebenso, “Fluoroquinolones as corrosion inhibitors for mild steel in acidic medium; experimental and theoretical studies”, Int. J. Electrochem. Sci, Vol.5, 1127–1150, 2010.
[5] N.O. Eddy and E.E. Ebenso, “Corrosion inhibition and adsorption characteristics of Tarivid on mild steel in H2SO4ˮ, E-Journal of Chemistry, Vol.7, 442–448, 2010.
[6] R.S. Abdel Hameed, “Ranitidine drugs as non-toxic corrosion inhibitors for mild steel in hydrochloric acid mediumˮ, Portugaliae Electrochimica Acta, Vol.29, No.4, 273–285, 2011.
[7] A.S. Fouda, S.M. Rashwan, M. Kamel and A.A. Badawy, “Unused Meropenem drug as corrosion inhibitor for copper in acidic medium experimental and theoretical studiesˮ, Int. J. Electrochem. Sci, Vol.11, 9745–9761, 2016.
[8] P. Singh, D.S. Chauhan, K. Srivastava, V. Srivastava and M.A. Quraishi, “Expired Atorvastatin drug as corrosion inhibitor for mild steel in hydrochloric acid solutionˮ, Int. J. Ind. Chem, Vol.10, 017–0120, 2016.
[9] M.E. Ikpi, F.E. Abeng, and B.O. Okonkwo, “Experimental and computational study of Levofloxacin as corrosion inhibitor for carbon steel in acidic mediaˮ, WNOFNS, Vol.9, 79–90, 2017.
[10] A. S. Fouda, K. Shalabi and A. E-Hossiany, “Moxifloxacin Antibiotic as Green Corrosion Inhibitor for Carbon Steel in 1 M HClˮ, J. Bio Tribo Corros, Vol.2, 2016, PP.2-13.
[11] R.A. Anaee, H.A. Majid, I.I. Slafa, A.A. Saja and S.M. Zahra`a, “Effect of (50% Isopropanol – 30%Methanol – 17%Xylene) mixture on corrosion behavior of pure Al and its alloys in simulated fuel”, Eng. & Tech. Journal, Vol. 33, Part (A), No. 6, 2014, 1380–1389.
[12] R.A. Anaee, “Properties of functionally graded coating of Al2O3/ZrO2/HAP on SS 316L”, International Journal of Scientific & Engineering Research, Vol. 6, Issue 5, May-2015.
[13] R.A. Anaee, “Study of Corrosion Behavior of Al-Si-Cu/WC Composites in 0.1 N NaOH Solution”, JKAU: Eng. Sci., Vol. 26 No.1, pp: 55- 65, 2015.
[14] A.S. Fouda, M.N. EL-Haddad and Y.M.Abdallah, “Septazole: Antibacterial Drug as a Green Corrosion Inhibitor for Copper in Hydrochloric Acid Solutions ˮ , International Journal of Innovative Research in Science, Engineering and Technology, Vol.2, 2013, PP.7073-7085.
[15] R.A. Anaee, M.A. Abbas, “Effect of nanoparticles coating on properties of Al-12Si Alloy”, International Journal of Scientific Research in Science, Engineering and Technology, Vol.1, No.2, 363–367, 2015.
[16] R.A. Anaee, “Corrosion inhibition by pumpkin peels extract in petroleum environment”, American Chemical Science Journal, Vol.5, No.1, 32–40, 2015.
[17] R.A. Anaee, “Corrosion inhibition of Al-Si-Cu alloy in the basic media by using six inhibitors at four temperatures”, Um-Salama Science Journal, Vol.5, No.2, 2008.
[18] A.S. Fouda, H.Ibrahim, S.Rashwaan, A. El-Hossiany and R.M. Ahmed, “ Expired Drug (pantoprazole sodium) as a Corrosion Inhibitor for High Carbon Steel in Hydrochloric Acid Solution ˮ, Int. J. Electrochem. Sci, Vol.13, 2018, PP.6327 – 6346.
[19] C. Mary anbarasi and Susai rajendran, “Electrochemical and AFMStudy of Corrosion Inhibition of Carbon Steel by Octanesulphonic Acid-Zinc Ion System ˮ, International Journal of Current Engineering and Technology, Vol.3, No.5, 2013, PP.2088-2093.